Table 5.
Pharmacokinetic parameters of 5-FU (100 mg/kg, iv) in rat.
| Parameter | Unit | 5-FU (100 mg/kg, iv) |
5-FU + XSLJZT (600 mg/kg/day, po) |
5-FU + XSLJZT (2400 mg/kg/day, po) |
|---|---|---|---|---|
| AUC | min μg/mL | 4527 ± 974 | 4640 ± 686 | 6343 ± 1272 * |
| C0 | μg/mL | 129.4 ± 14.4 | 140.9 ± 13.6 | 150.9 ± 11.5 |
| t½ | min | 32 ± 12.0 | 50 ± 15.1 * | 50 ± 1.51 * |
| Cl | mL/min/kg | 22.87 ± 4.39 | 21.97 ± 3.43 | 16.32 ± 3.39 * |
| Vss | mL/kg | 770.2 ± 52.1 | 815.4 ± 115 | 1084 ± 188 ** |
| MRT | min | 35 ± 7.06 | 38 ± 6.91 | 67 ± 4.76 ** |
AUC, area under the concentration versus time curve; C0, initial drug concentration; Cl clearance; t½, elimination half-life; Vss, volume of distribution at steady state; MRT, mean residence time. Cl = Dose/AUC; Vss = Dose/C0; MRT = AUMC/AUC. Data are expressed as the means ± SD (n = 6). * p < 0.05 and ** p < 0.01 compared with that of the 5-FU alone group. po: by mouth; iv: intravenous.