Table 6.
Pharmacokinetic parameters of 5-FDHU is a metabolite of 5-FU.
| Parameter | Unit | 5-FU (100 mg/kg, iv) |
5-FU + XSLJZT (600 mg/kg/day, po) |
5-FU + XSLJZT (2400 mg/kg/day, po) |
|---|---|---|---|---|
| AUC | min μg/mL | 321.8 ± 59.7 | 384.0 ± 19.9 | 354.2 ± 45.4 |
| Cmax | μg/mL | 2.904 ± 0.54 | 3.849 ± 0.36 | 3.688 ± 0.34 |
| Tmax | min | 60 | 60 | 45 ± 16.4 |
| t½ | min | 71 ± 9.62 | 68.00 ± 19.9 | 83 ± 32.4 |
| Cl | mL/min/kg | 320.0 ± 61.2 | 261.0 ± 13.4 | 286.8 ± 42.8 |
| MRT | min | 110 ± 18.5 | 102 ± 15.0 | 105 ± 18.7 |
AUC, the area under the concentration versus time curve; Cmax, the maximum concentration; Tmax, the time taken to reach the maximum concentration; Cl, the clearance; t½, the elimination half-life; MRT, mean residence time. Cl = Dose/AUC; MRT = AUMC/AUC. Data are expressed as the means ± SD (n = 6). * p < 0.05 and ** p < 0.01 compared with that of the 5-FU alone group. po: by mouth; iv: intravenous.