Table 1.
Role of BMP signalling modulators in liver fibrosis. CTGF: Connective tissue growth factor; KPC: Kielin/chordin-like protein.
| Potential Effect on Liver Fibrosis | Regulatory Effect on BMP Signaling in Liver Fibrosis | References | |
|---|---|---|---|
| Endoglin | Profibrotic | Not determined. Indirect data would support a stimulatory effect on BMP signaling |
[132,133,134] |
| CTGF | Profibrotic | CTGF does not interfere with BMP7 signaling BMP7 inhibits CTGF expression |
[135,136,137] |
| Gremlin | Profibrotic | It inhibits BMP7 antifibrotic signaling | [138,139,140] |
| KCP | Antifibrotic | Not determined | [141] |
| Follitastin | Antifibrotic | Not determined | [142,143] |
| Bambi | Antifibrotic | Not determined | [144,145] |