The effects of PVN microinjection of saline, polyethylene glycol-superoxide dismutase (PEG-SOD) (5 units) and diethyldithiocarbamic acid (DETC, 10 nmol) on the baseline RSNA and MAP (A), and on CSAR (B) in the PVN in control, OR, OB, and OH rats. The values are mean ± SE. For each group, n = 6; * p < 0.05 versus saline; # p < 0.05 versus control; $ p < 0.05 versus OR; % p < 0.05 versus OB. PVN: paraventricular nucleus; CSAR: cardiac sympathetic afferent reflex; RSNA: renal sympathetic nerve activity; MAP: mean artery pressure; OB: obesity without hypertension; OH: obesity-related hypertension; DETC: superoxide dismutase inhibitor.