Table 4.
Selected molecular pathways significantly regulated by differentially expressed miRNAs in subcutaneous (SAT) and visceral (VAT) adipose tissues of normal-weight (N), obese (O) and after weight loss (PO) individuals. Values presented as fold enrichment (values >1 correspond to the overrepresentation of the particular pathway while values <1 to its underrepresentation).
| Fold Enrichment | ||||
|---|---|---|---|---|
| SAT-O vs. SAT-N | SAT-PO vs. SAT-O | SAT-PO vs. SAT-N | VAT-O vs. SAT-O | |
| Pathways corrected * | ||||
| Inflammation mediated by chemokine and cytokine signaling pathway (P00031) | 1.22 | −1.13 | −1.14 | 1.17 |
| Wnt signaling pathway (P00057) | −1.53 | |||
| CCKR signaling map (P06959) | 1.35 | |||
| Pathways non corrected ** | ||||
| Beta2 adrenergic receptor signaling pathway (P04378) | −2.46 | |||
| Interleukin signaling pathway (P00036) | 1.23 | |||
| Endothelin signaling pathway (P00019) | 1.46 | |||
| Apoptosis signaling pathway (P00006) | 1.25 | 1.81 | −1.23 | −1.47 |
| p53 pathway (P00059) | 1.30 | 1.78 | −1.28 | −1.68 |
| p53 pathway by glucose deprivation (P04397) | 1.63 | |||
| Alzheimer disease-presenilin pathway (P00004) | −1.28 | −1.47 | ||
| Glycolysis (P00024) | 3.55 | −2.64 | ||
| Cholesterol biosynthesis (P00014) | −2.44 | |||
* Pathways that passed the Bonferroni correction; ** Pathways that did not pass the Bonferroni correction.