Figure 4.

Glycyrrhizic acid (GA) inhibited keloid fibroblast activity. Scale bar: 50 μm. (A) The in vitro wound healing assay showed decreased keloid fibroblast migration after GA treatment; (B) The cell tracking system for fibroblast migration was analyzed using cells selected from both sides of the wound, keloid fibroblasts were tracked toward the site of wound insert after cultivation for 24 h; black, cells toward the midline from the left edge; red, cells toward the midline from the right edge. GA-induced decreases in the average migration speed (C) and the average distance (D) traveled of keloid fibroblasts. All results are shown as mean ± SD (* p < 0.05).