Table 2.
Analog | Conc. (µM) | Inhibition (%) ± SEM [Calculated IC50 Value (µM)] | |||
---|---|---|---|---|---|
HeLa | A2780 | MCF7 | MDA-MB-231 | ||
3 | 10 | 29.83 ± 1.65 | 96.66 ± 0.23 | 35.07 ± 2.64 | 19.06 ± 2.98 |
30 | 98.46 ± 0.08 | 96.60 ± 0.37 | 93.00 ± 0.68 | 84.58 ± 1.87 | |
[12.23] | [1.44] | [12.37] | [16.47] | ||
4 | 10 | 37.96 ± 2.20 | 96.28 ± 0.32 | 49.99 ± 0.80 | 33.33 ± 1.94 |
30 | 98.17 ± 0.19 | 96.82 ± 0.18 | 96.08 ± 0.52 | 89.95 ± 0.90 | |
[11.46] | [1.91] | [10.02] | [13.02] | ||
5 | 10 | 21.94 ± 2.94 | 91.95 ± 0.26 | 28.62 ± 1.98 | 20.31 ± 1.45 |
30 | 96.31 ± 0.33 | 93.77 ± 0.27 | 85.27 ± 1.84 | 58.06 ± 1.75 | |
[13.62] | [2.05] | [14.54] | [24.28] | ||
6 | 10 | – * | 56.80 ± 3.18 | 17.30 ± 1.74 | 19.61 ± 2.23 |
30 | 47.39 ± 2.99 | 93.34 ± 0.69 | 23.87 ± 2.37 | 29.68 ± 2.54 | |
7 | 10 | – | 15.35 ± 1.79 | 19.80 ± 1.99 | – |
30 | 24.18 ± 2.42 | 36.92 ± 1.39 | 23.44 ± 1.86 | 24.66 ± 1.38 | |
8 | 10 | – | 12.18 ± 1.70 | 14.62 ± 2.49 | 11.71 ± 0.74 |
30 | 12.31 ± 2.25 | 36.58 ± 1.38 | 35.75 ± 2.79 | 20.27 ± 2.62 | |
9 | 10 | – | – | – | 11.45 ± 2.75 |
30 | 10.83 ± 2.40 | 34.56 ± 1.83 | – | 21.57 ± 1.69 | |
10 | 10 | – | 17.93 ± 1.06 | – | 11.43 ± 1.68 |
30 | 26.01 ± 0.74 | 48.27 ± 0.64 | 44.00 ± 1.34 | 24.67 ± 2.13 | |
11 | 10 | 12.36 ± 1.23 | – | – | – |
30 | 13.41 ± 1.87 | 28.44 ± 0.92 | 25.32 ± 1.10 | 10.36 ± 2.14 | |
12 | 10 | – | – | – | 15.51 ± 2.77 |
30 | – | 31.13 ± 2.48 | – | 15.92 ± 2.69 | |
13 | 10 | – | 11.76 ± 0.76 | – | – |
30 | – | 48.66 ± 1.97 | – | 18.81 ± 2.59 | |
14 | 10 | – | – | – | – |
30 | – | 29.12 ± 2.32 | 14.46 ± 2.31 | 16.28 ± 1.85 | |
cisplatin | 10 | 42.61 ± 2.33 | 83.57 ± 1.21 | 53.03 ± 2.29 | 67.51 ± 1.01 |
30 | 99.93 ± 0.26 | 95.02 ± 0.28 | 86.90 ± 1.24 | 87.75 ± 1.10 | |
[12.43] | [1.30] | [5.78] | [3.74] |
* Growth inhibition values less than 10% are considered negligible and not given numerically.