Table 2.
List of significantly differentially expressed proteins identified in human plasma between hypothyroid vs. euthyroid states using 2D-DIGE. Differences in fold change are shown. Protein name, accesion number, Mascot score, MS% coverage, protein MW, and pI values according to Uniprot database are listed.
| Accession No a | MASCOT ID | Protein Name | Pi b | MW c | Coverage % | Score d | Ratio of Hypothyroid/Euthyroid | Fold Change e | p-Value |
|---|---|---|---|---|---|---|---|---|---|
| P06681 | CO2_HUMAN | Complement C2 | 7.23 | 83,268 | 22 | 64 | up | 3.3 | 0.002 |
| P02787 | TRFE_HUMAN | Serotransferrin | 6.81 | 77,000 | 45 | 67 | up | 2.2 | 0.002 |
| P01024 | CO3_HUMAN | Complement C3 | 6.39 | 187,030 | 14 | 60 | up | 1.7 | 0.006 |
| P01834 | IGKC_HUMAN | Ig κ chain C region | 6.11 | 11,602 | 85 | 57 | up | 2.2 | 0.009 |
| P01011 | AACT_HUMAN | α-1-antichymotrypsin | 5.33 | 47,621 | 27 | 72 | up | 2.3 | 0.009 |
| P0C0L4 | CO4A_HUMAN | Complement C4-A | 6.66 | 1,926,500 | 28 | 63 | up | 3.4 | 0.01 |
| P00738 | HPT_HUMAN | Haptoglobin | 6.3 | 45,177 | 68 | 60 | up | 1.9 | 0.015 |
| P02671 | FIBA_HUMAN | Fibrinogen α chain | 5.10 | 94,914 | 23 | 75 | up | 1.7 | 0.010 |
| P02647 | APOA1_HUMAN | Apolipoprotein A-I | 5.56 | 30,759 | 34 | 69 | up | 2.2 | 0.013 |
| P01876 | IgGA1_HUMAN | Ig α-1 chain C region | 6.08 | 37,631 | 45 | 166 | up | 1.5 | 0.042 |
| P08603 | CFAH_HUMAN | Complement factor H | 6.23 | 139,068 | 27 | 72 | down | 2.5 | 0.033 |
| P0CW24 | PNM6A_HUMAN | Paraneoplastic antigen-like protein 6A | 5.24 | 43,875 | 35 | 133 | down | 2.1 | 0.034 |
| P01023 | A2MG_HUMAN | α-2-macroglobulin | 6.00 | 163,189 | 27 | 69 | down | 1.9 | 0.035 |
MW-molecular weight; a Protein accession number for SWISSPROT Database; b Theoretical isoelectric point; c Theoretical relative mass; d MASCOT score; e Protein expression between hypothyroid and euthyroid states.