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. 2018 Jan 3;19(1):129. doi: 10.3390/ijms19010129

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cellular and humoral response induced in BALB/c mice before infection. Spleen cells were obtained from experimental mice 30 days after the last vaccine dose and before infection. These were cultured in the absence (medium) or presence of rSMP-3 or SLA (5 and 20 µg/mL, respectively). IFN-γ, IL-12, GM-CSF, IL-4, and IL-10 levels were measured by capture ELISA in the cell supernatants (a). The SMP-3 and parasite-specific IgG1 and IgG2a isotype levels were determined, and ratios between IgG2a and IgG1 were calculated and are shown (b). Bars represent the mean ± standard deviation. * indicates statistically significant differences (p < 0.005) between the rSMP-3/saponin group and the control (saline and saponin) groups.