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. 2018 Jan 3;19(1):132. doi: 10.3390/ijms19010132

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Retinoid transport pathways within an animal organism. Various metabolic forms of retinoids are shown in relation to their localization, transport, and fate. Red dots indicate key players with described role in different mechanisms of resistance to retinoids. LRAT: lecithin-retinol acyltransferase; REH: retinyl ester hydrolase; STRA6: receptors stimulated by retinoic acid 6; ABC: ATP-binding cassette; RALR: retinal reductase; RDH: retinol dehydrogenase; CRABP: cellular retinoic acid binding proteins.