Figure 1.

Workflow of structure-based drug design. The amino-acid sequences of staphylococcal enterotoxins A (SEA) and B-like (SEB-L) were obtained from National Center for Biotechnology Information (NCBI). The amino- acid sequences were blast-searched against the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB) to identify the related protein structures that were subsequently used as templates in homology modeling. The quality and reliability of the generated models were assessed by NAMD 2.5 (NAnoscale Molecular Dynamics 2.5), PROCHECK and ERRAT programs.