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. 2018 Jan 6;19(1):167. doi: 10.3390/ijms19010167

Figure 4.

Figure 4

New MO sequences are able to upregulate the SMN protein in heterozygous SMA mice. (A) A representative image of western blot and densitometry analyses of brain samples from heterozygous SMA mice treated with different MO sequences shows that the efficacy of co-administration of MO B + MO D was high, even if not as high as MO-10-34 (** p < 0.01); (B) A representative image of western blot and densitometry analyses of spinal cord samples from heterozygous SMA mice treated with different MO sequences shows that co-administration of MO B + MO D was more efficacious than treatment with other sequences, even more so than treatment with MO-10-34 (p < 0.01). The values represent the means + SEM. Scr-MO: scrambled-MO.