Figure 5.

Effect of valproate (VPA), 200 and 20,000 µg/kg, and resveratrol, 680 and 6800 μg/kg, administered individually or in combination (VPA 200 μg/kg + resveratrol 680 µg/kg) in mice subjected to 60 min of middle cerebral artery occlusion (MCAO). Drugs were administered 30 min after the end of the MCAO period and evaluation of brain damage was performed 24 h after ischemia induction. (A) Effect of drug administration on ischemic damage. Each column represented the mean ± s.e.m. of the percentage of the infarct volume compared with the ipsilateral hemisphere. * p < 0.05 versus vehicle-treated group; (B,C) Effect of diverse doses of VPA and resveratrol, individually or in combination, on general and focal neurological scores, evaluated 24 h after the ischemia induction. * p < 0.05 versus vehicle-treated animals.