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Schematic diagram of fusion proteins of NKG2D (natural killer group 2, member D)/NKG2D ligands (NKG2DLs) in cancer immunotherapy. Fc, fragment crystallizable region of an antibody; ADCC, antibody-dependent cell-mediated cytotoxicity; CD3, cluster of differentiation 3; DAP10, hematopoietic cell signal transducer; PI3K, phosphatidylinositol-3 kinase; Grb2, growth factor receptor-bound protein 2; Vav1, vav guanine nucleotide exchange factor 1; CAR, chimeric antigen receptors.
