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. 2018 Jan 8;19(1):187. doi: 10.3390/ijms19010187

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The protocatechuic acid (PCA) treatment reduces the number of degenerating neurons after a seizure. Three days of the PCA treatment reduces the number of seizure-induced degenerating neurons. Fluoro-Jade-B (FJB) staining was performed to visualize the degenerating neurons. (A) A series of photographs showing degenerating neurons in the control group and the PCA-treated group after a seizure. Scale bar = 100 μm. (B) The graph represents the number of FJB⁺ neurons in the hippocampus after a seizure. Data: mean ± standard error of the mean (SEM), n = 5–7 from each group. * p < 0.05. Veh = Vehicle; CA1 and CA3 = Cornu Ammonis 1 and 3 of the hippocampus area; Sub = Subiculum.