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OGA overexpression rescued BMP2-induced osteogenic differentiation under excessive O-GlcNAcylation conditions. C2C12 cells were transfected with OGA expression plasmids and osteogenic differentiation was induced by BMP2 in the presence or absence of N-acetylglucosamine (GN). Subsequently, ALP staining and ALP activity assays (A) or qRT-PCR analysis (B) were performed. * p < 0.05 compared with the non-treatment control; # p < 0.05 for the indicated pairs.
