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. 2018 Jan 9;19(1):203. doi: 10.3390/ijms19010203

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Calcitonin Gene Related Peptide (CGRP) expression in C5 spinal dorsal horn. (a) control group, (b) Saline group: CGRP is expressed in the posterior horn, (c) monoiodoacetate (MIA)+/mesenchymal stem cell (MSC)− group: CGRP is intensely expressed, (d) MIA+/MSC− group: CGRP expression as compared with MIA+/MSC− group is clearly decreased, and is suppressed to about the same degree in control and Saline group. In MIA+/MSC− group a significant increase is found, indicating that central sensitization has occurred. With MSC administration, as compared with MIA+/MSC− group a significant decrease is found meaning that central sensitization has been inhibited. * p < 0.001 compared to the untreated control. ^# p < 0.001 compared to the (MIA+/MSC−) group.