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. 2018 Jan 12;19(1):231. doi: 10.3390/ijms19010231

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic depicting the possible interactions between MCs and fibroblasts in the heart. (Left) MCs may act in a paracrine manner to signal only to fibroblasts in their local area. This would limit direct MC-fibroblast interactions as a mechanism by which MCs cause fibrosis; (Right) Alternatively, MC products may be taken up in the general coronary circulation allowing their products to be distributed to fibroblasts throughout the heart. This would allow for greater MC-fibroblast interactions.