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. 2018 Jan 16;19(1):271. doi: 10.3390/ijms19010271

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analyses of TF-mRNA and TF-miRNA networks in P-N1ICD vs. P-Control. (A) The network of TF-mRNA in P-N1ICD vs. P-Control; red circular represents upregulated DEGs; green circular represents downregulated DEMs; red V-shape represents upregulated TFs; and green V-shape represents downregulated TFs. (B) The sequence logo display for transcription factors of SNAI2 and EGR1 whose binding sites are significantly enriched in the regulation of DEGs in P-N1ICD vs. P-Control. (C) The network of TF-miRNA in P-N1ICD vs. P-Control; red triangle represents upregulated DEMs; green triangle represents downregulated DEMs; red V-shape represents upregulated TFs; and green V-shape represents downregulated TFs. (D) The sequence logo display for transcription factors of snail family transcriptional repressor 2 (SNAI2) and early growth response 1 (EGR1) whose binding sites are significantly enriched in the regulation of DEMs in P-N1ICD vs. P-Control.

Analyses of TF-mRNA and TF-miRNA networks in P-N1ICD vs. P-Control. (A) The network of TF-mRNA in P-N1ICD vs. P-Control; red circular represents upregulated DEGs; green circular represents downregulated DEMs; red V-shape represents upregulated TFs; and green V-shape represents downregulated TFs. (B) The sequence logo display for transcription factors of SNAI2 and EGR1 whose binding sites are significantly enriched in the regulation of DEGs in P-N1ICD vs. P-Control. (C) The network of TF-miRNA in P-N1ICD vs. P-Control; red triangle represents upregulated DEMs; green triangle represents downregulated DEMs; red V-shape represents upregulated TFs; and green V-shape represents downregulated TFs. (D) The sequence logo display for transcription factors of snail family transcriptional repressor 2 (SNAI2) and early growth response 1 (EGR1) whose binding sites are significantly enriched in the regulation of DEMs in P-N1ICD vs. P-Control.