Table 1.

Clinical and histopathological data of the patients analyzed in this study. (A) Higher or similar expression of TERRA in tumor compared to normal tissue (n = 14); (B) Lower expression of TERRA in tumor compared to normal tissue (n = 9).

No.	Sex/Age	Tumor Site	Staging (pTNM)	Grading	HPV Status	Date of Sampling	Status at 15 December 2017	DFS (Months)
A
9	F/71	Oropharynx	T4a, N0, M0	G2	Negative	15 April 2011	Dead of disease on 24 June 2013	26
35	M/67	Oropharynx	T3, N0, M0	G2	Negative	1 March 2012	Alive. On 15 December 2014, a second primary tumor (SCC of the tongue staged pT2, N2, M0, graded G2) was resected	33+
38	M/64	Tongue	T2, N0, M0	G2/G3	ND	16 December 2013	Alive, disease-free	48+
2	M/70	Hypopharynx	T4a, N2b, M0	G2	ND	10 September 2013	Alive, disease-free	51+
37	M/66	Oropharynx	T4a, N0, M0	G1/G2	Negative	26 March 2012	Alive, disease-free	68+
22	M/68	Tongue	T3, N0, M0	G2	ND	12 April 2010	Lost at follow-up on 9 May 2016, when was alive and disease-free	72+
28	F/79	Larynx	T3, N0, M0	G2/G3	ND	15 July 2011	Alive, disease-free	77+
20	M/59	Larynx	T4a, N0, M0	G2	ND	8 February 2011	Alive, disease-free	82+
7	M/55	Larynx	T4a, N0, M0	G2	ND	24 January 2011	Alive, disease-free	82+
18	M/79	Hypopharynx	T2, N2, M0	G2/G3	ND	17 January 2011	Alive, disease-free	82+
21	M/72	Tongue	T3, N1, M0	G2/G3	ND	1 June 2010	Alive, disease-free	90+
17	M/52	Oropharynx	T2, N0, M0	G2	Negative	24 May 2010	Alive, disease-free	90+
14	M/59	Larynx	T4a, N0, M0	G2	ND	20 July 2009	Alive, disease-free	100+
3	M/52	Pharynx	T4a, N0, M0	G3/G3	ND	26 February 2009	Alive, disease-free	105+
B
No.	Sex/Age	Tumor Site	Staging (pTNM)	Grading	HPV Status	Date of Sampling	Status at 15 December 2017	DFS (Months)
10	M/65	Cervical esophagus	T2, N0, M1 (liver)	G2	ND	24 October 2013	Dead of disease on 21 March 2014	4
34	F/77	Hypopharynx	T3, N0, M0	G2	ND	26 November 2010	Dead of disease on 6April 2011	4
24	F/71	Oropharynx	T4a, N1, M0	G2	Negative	21 February 2011	Dead of disease on 19 November 2011	8
6	M/59	Hypopharynx 1	T4a, N0, M0	G2	ND	20 October 2011	Dead of disease on 10 February 2013	15
26	M/70	Oropharynx 1	T2, N0, M0	G2	Negative	7 July 2011	Dead of disease on 22 October 2013	27
11	M/58	Tongue	T3, N1, M0	G2	ND	28 September 2009	Dead of disease on 10 February 2012	28
27	F/63	Tongue	T3, N0, M0	G2	ND	11 July 2011	Dead of disease on 18 May 2014	34
19	M/70	Larynx	T4a, N2, M0	G2	ND	31 January 2011	Alive, disease-free (for head and neck tumor). On 6 March 2017 a second primary tumor (hepatocellular carcinoma, HCC) on a chronic HCV (hepatitis C virus) infection was diagnosed. The HCC was treated by means of RTFA and has not recurred to date.	82+
25	F/62	Larynx 1	T2, N2, M0	G2	ND	19 July 2011	Alive, disease-free	88+

¹ All these patients were previously operated for a distinct tumor of the head and neck district; pTNM: pathological tumor node metastasis; HPV: human papilloma virus; DFS: disease-free survival; M: male; F: female; SSC: squamous cell carcinoma; HCC: hepatocellular carcinoma; ND: No Data.