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. 2018 Jan 17;19(1):282. doi: 10.3390/ijms19010282

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of nCMFC on rabbit eyes. (A) Solubility of MH in nCMFC in saline and lacrimal fluid; (B) changes in amount of lacrimal fluid after repetitive instillation of nCMFC for 4 weeks (twice/day); (C) image of rabbit eye after the repetitive instillation of nCMFC for 4 weeks (twice/day); (D) viability of human corneal epithelial cell line cells (HCE-T) cells treated with nCMFC. None, non-treated groups. Vehicle, vehicle-instilled groups. nCMFC, nCMFC-instilled groups. n = 6–12. Solubility of MH in nCMFC in lacrimal fluid was low (0.00037%), and the behavior of lacrimal fluid (balance of secretion and excretion) was similar between rabbit eyes instilled with or without nCMFC. In addition, the corneal toxicity of nCMFC was not observed in the rabbit cornea and HCE-T cells.