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. 2018 Jan 17;19(1):282. doi: 10.3390/ijms19010282

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Preventive effect of nCMFC on the increased IOP in a rabbit model. Rabbits were kept in a dark room for 5 h before the experiment. Saline (○), saline-instilled rabbit. CRT-solution (●), CRT-solution-instilled rabbit. mCMFC (▲), mCMFC-instilled rabbit. nCMFC (■), nCMFC-instilled rabbit. n = 6–8. *¹ p < 0.05, vs. Saline for each category. *² p < 0.05, vs. CRT-solution for each category. *³ p < 0.05, vs. mCMFC for each category. The IOP-reducing effect of carteolol was remarkably enhanced by its combination with MH nanoparticles.