Table 3. List of predicted molecular functions with a group of identified proteins in the DENV2-infected and not infected HepG2 cells with YK51 treatment based on Ingenuity Pathway analysis.

Samples	Gene names	Gene symbols	Types	Locations	Diseases and functions annotation
DENV2-infected HepG2 cells with YK51 treatment	Protein disulfide isomerase family A, member 6	PDIA6	Enzyme	Cytoplasm	Viral Infection
	Protein disulfide isomerase family A, member 3	PDIA3	Peptidase	Cytoplasm
	Proteasome 26S subunit, ATPase, 5	PSMC5	Transcription regulator	Nucleus
	Mitogen-activated protein kinase 1	MAPK1	Kinase	Cytoplasm
	Transaldolase 1	TALDO1	Enzyme	Cytoplasm
	Glutamic pyruvate transaminase 2	GPT2	Enzyme	Cytoplasm
	ATP synthase	ATP5B	Transporter	Cytoplasm
	Heat shock 70kDa protein 9	HSPA9	Other	Cytoplasm
YK51-treated HepG2 cells	Annexin IV	ANXA4	Other	Plasma membrane	–	Cell death
	COP9 signalosome complex subunit 5	COPS5	Transcription regulator	Nucleus	Proliferation of cells
	Deoxythymidylate kinase	DTYMK	Kinase	Cytoplasm
	Protein phosphatase 1, catalytic subunit, alpha isoform	PPP1CA	Phosphatase	Cytoplasm
	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	PPP2R1A	Phosphatase	Cytoplasm