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. 2018 Jan 18;2(2):211–222. doi: 10.1002/hep4.1135

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© 2018 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Pro‐C3/C3M ratio and disease severity in TIPS patients. (A) Significantly higher Pro‐C3/C3M ratio in patients with HRS. (B) Significantly higher Pro‐C3/C3M ratio in patients with severe ascites. (C) Patients with MELD score >11 and Child‐Pugh C show a significantly higher Pro‐C3/C3M ratio. (D) Significantly higher Pro‐C3/C3M ratio in patients with CLIF‐C AD score >49.5, and patients with Pro‐C3‐/C3M ratio >1.5 show significantly higher CLIF‐C AD scores. (E) Significant correlation of Pro‐C3/C3M ratio with ACLF. (F) Kaplan‐Meier stratified for Pro‐C3/C3M ratio at a threshold of 1.5 in the hepatic vein. *P < 0.05, **P < 0.01, ***P < 0.001; data represent mean ± SEM.