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. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):482–487. doi: 10.1038/nature23909

Extended Data Fig. 12. Distinct populations of S1DZ neurons projecting to TeA or Striatum selectively modulate marble burying and sociability phenotypes.

Extended Data Fig. 12

a, Percentage of EYFP/c-Fos co-expressing neurons upon stimulation of animals described in Fig. 5c (n=6/6/6/6-mice, 3-independent experiments (PBS;RV-EYFP/Chronos/ArchT, MIA;RV-ArchT)). b–f, Performance on the marble burying test (b) (‘Laser On-Off’: n=4/8/5/7-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 4/7/5/7-independent experiments and ‘Laser Off-On’: n=5/5/5/5-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 5/5/5/5-independent experiments), the % social target (c) and the total interaction time during the sociability test (d) (‘Laser On-Off’: n=4/6/9/9-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 4/5/7/7-independent experiments and ‘Laser Off-On’: n=6/6/6/6-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 5/5/5/5-independent experiments), and the time spent in center (e) and the total distance moved during the open field test (f) (‘Laser On-Off’: n=4/4/3/5-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 4/4/3/5-independent experiments and ‘Laser Off-On’: n=3/3/4/6-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 3/3/4/5-independent experiments). g, Percentage of EYFP/c-Fos co-expressing neurons upon stimulation of animals described in Fig. 5i (n=6/6/6/6-mice, 3-independent experiments (PBS;RV-EYFP/Chronos/ArchT, MIA;RV-ArchT)). h–l, Performance on the marble burying test (h) (‘Laser On-Off’: n=4/4/4/4-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 4-independent experiments and ‘Laser Off-On’: n=3/4/4/4-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 3-independent experiments), the % social target (i) and the total interaction time during the sociability test (j) (‘Laser On-Off’: n=4/3/3/3-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 3-independent experiments and ‘Laser Off-On’: n=3/3/3/4-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 3-independent experiments), and the time spent in center (k) and the total distance moved during the open field test (l) (‘Laser On-Off’: n=3/5/4/6-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 3/5/4/5-independent experiments and ‘Laser Off-On’: n=2/4/4/4-mice for PBS;EYFP/PBS;Chronos/PBS;ArchT/MIA;ArchT, 2/4/4/4-independent experiments).