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. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):482–487. doi: 10.1038/nature23909

Figure 1. Cortical patches observed in offspring of dams following MIA.

Figure 1

a, Representative S1 image of adult MIA offspring. Arrow indicates cortical patch. Scale bar, 500μm. b, Prevalence of cortical patches (n=10-mice/2-independent experiments) in MIA offspring. c, Superimposed image of cortical patches within AP 0.38–1.34mm (n=50-mice/12-independent experiments). The mouse brain in this figure has been reproduced with permission from Paxinos. Scale indicates frequencies of patches (high=red; low=blue). d, Representative images of S1. White dotted-lines indicate boundary of cortical patches. Scale bar, 100μm. e, Quantification of SATB2+/PV+/VIP+/NeuN+ cells in S1cortical patches (n=4/4-mice (PBS/Poly(I:C)), 3-independent experiments for SATB2/VIP/NeuN; n=5/5-mice (PBS/Poly(I:C)), 3-independent experiments for PV). f, Representative images of c-Fos expression in S1. Scale bar, 100μm. g, Quantification of c-Fos expression in S1 (n=4/4-mice (PBS/Poly(I:C)); 3-independent experiments). *p<0.05,**p<0.01 as calculated by two-way repeated measures ANOVA with Tukey (e) and two tailed unpaired t-test (g). Graphs indicate mean±s.e.m.