Skip to main content
. Author manuscript; available in PMC: 2018 Mar 13.
Published in final edited form as: Nature. 2017 Sep 13;549(7673):482–487. doi: 10.1038/nature23909

Figure 4. Reducing neural activity in the S1DZ region corrects behavioral abnormalities in MIA offspring.

Figure 4

a, Representative images of c-Fos expression upon photostimulation of the S1DZ region in MIA offspring. Scale bar, 100μm. b, Percentage of EYFP/c-Fos co-expressing neurons upon stimulation (n=6/6/6-mice; 3-independent experiments (MIA;AAV2-hSyn-EYFP/ChR2/NpHR)). c–f, Performance on marble burying test (c), % interaction (d) and total interaction time (e) during the sociability test, and time spent in center during the open field assay (f) (n=8/11/10/20-mice; 5/5/5/7-independent experiments (PBS;AAV2-hSyn-EYFP/MIA;AAV2-hSyn-EYFP/ChR2/NpHR)). *p<0.05,**p<0.01 as calculated by two-way ANOVA (d) and one-way ANOVA (b,c,e,f) with Tukey post-hoc tests. Graphs indicate mean±s.e.m.