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. 2017 Dec 22;10(1):10–24. doi: 10.1080/19382014.2017.1405189

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© 2018 The Author(s). Published by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Low AGE dietary exposure reduces pancreatic CML and RAGE expression. Representative images of pancreatic sections from 28 day old NOD8.3⁺ mice fed a high AGE diet (HAGE; left panel) or low AGE diet (LAGE; right panel) after chromogen detection (DAB) using antibodies against CML (A), RAGE (D) and AGE-R1 (G) (n = 5–7/group). Scale bar represents 50 µm. The percentage of DAB⁺/islet and DAB reciprocal intensity from CML (B, C), RAGE (E, F) and AGE-R1 (H, I) were quantified using Visiopharm software (n = 2 serials sections/mouse, 29 ± 15 islets/mouse). Median is represented in quantification plots with single islets shown as either as circles (HAGE) or squares (LAGE). ****p < 0.0001 Mann Whitney U Test.