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. Author manuscript; available in PMC: 2018 Feb 2.
Published in final edited form as: Chemistry. 2014 Sep 10;20(44):14410–14420. doi: 10.1002/chem.201403372

Figure 7.

Figure 7

Inhibitory effect of complex 4 and 5 on T98G solid brain tumor cells. Percentage of viable T98G cells counts after treatment by (A) complexes 4, and (B) complex 5 at 24, 48 and 72 h. Data obtained by growth kinetics assay (A and B) showed that complexes 4 and 5 have an inhibitory effect on T98G cells that is dependent upon incubation time. The cultured cells were treated with 0.5 to 16 μM concentrations of the complexes. (C) Clonogenic capacity of T98G cells treated with complex 4, and 5. (D) Loss of growth-inhibiting activity of the complexes pre-incubated in culture medium. Complexes 4 and 5, at a concentration of 6 μM, were pre-incubated in DMSO and cell culture medium (DMEM) supplemented with 10% FBS at 37°C for the indicated times before being added to cultures of T98G cells.