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. 2018 Feb 1;6:23. doi: 10.1186/s40168-018-0401-z

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Preprocessing and UNIPROT ARGs annotation. Antibiotic resistance genes from CARD, ARDB, and UNIPROT were merged and clustered to remove duplicates. Then, sequences from UNIPROT are annotated using the matches between the metadata and the names of antibiotic categories from ARDB and CARD