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PSMC6 was the only gene producing resistance to BTZ after knocking out by CRISPR sgRNA. (A) Schematic diagram for genome wide sgRNA screen. (B) Top gene list for first round screen. (C) Top gene list for second screen. (D) Three independent experiments (MTT assay) of RPMI8226 cells knocked out by a mix of four PSMC6 sgRNAs (A+B+C+D). (E) PSMC6 knock out by three independent sgRNAs produces resistance to bortezomib (BTZ).
