Fig 7. Schematic overview of the main differences in the metabolite change associated with drug resistance of Candida albicans.

The differentially produced metabolites are mainly involved in amino metabolism, sphingolipid metabolism, TCA cycle, oxidative stress, glutathione metabolism and lipid metabolism. Metabolites in red marks are only related to drug stress; metabolites in blue marks are only related to strain type or drug resistance level; metabolites marked green are associated with the three described above.