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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Clin Cancer Res. 2017 Aug 24;24(3):521–531. doi: 10.1158/1078-0432.CCR-17-1597

Figure 2.

Figure 2

Examples of positive and negative RB expression by immunohistochemistry. (A and B, 100×) Positive RB expression. The nuclei of non-neoplastic colonic mucosa and submucosa (A) and colonic adenocarcinoma (B, white arrow) exhibit diffuse strong nuclear labeling. (C, 100×) Loss of RB expression in lung adenocarcinoma. Loss of nuclear staining in neoplastic cells (blue counterstain nuclei, black arrow), while adjacent non-neoplastic stromal cells and lymphocytes have retained nuclear expression (dark brown nuclei, white arrow).