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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Clin Cancer Res. 2017 Aug 24;24(3):521–531. doi: 10.1158/1078-0432.CCR-17-1597

Table 2.

Interpretation guidelines.

Staining Pattern Positive Therapy-guiding Alteration Lack of Therapy-guiding Alteration Indeterminate Results
PTEN Cytoplasmic Loss of expression
(Absent)		 Retained expression
(Retained)

  • Non-neoplastic elements weak*

  • Incongruent staining pattern

  • Insufficient sample
RB Nuclear
MLH1
MSH2
*

Staining should be repeated in such a situation before indeterminate category is assigned.