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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Neurotoxicology. 2017 Aug 2;64:185–194. doi: 10.1016/j.neuro.2017.07.026

Figure 3. LY294002 and NU7441 can reduce Mn-induced p-AKT and p-S6 expression at concentrations near the IC50 for PI3K.

Figure 3

A, B) Representative western blots for p-AKT(Ser473) or p-S6(Ser235/236) with Mn and/or SMI for 24 hours. Coomassie stain (total protein, below) was used as a loading control. C,D) Quantification of p-AKT(Ser473) or p-S6(Ser235/236) from western blots (n=3). All Mn + SMI values were compared with Mn alone by t-test. *p<0.05, **p<0.01. Error bars = SEM.