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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Mucosal Immunol. 2017 Aug 2;11(2):449–461. doi: 10.1038/mi.2017.59

Figure 1. MGN1703 induced an increase in MX1 and ISG15 positive cell profiles in the sigmoid colon.

Figure 1

(a) The timing of MGN1703 dosing and sample collection are illustrated. (b) Representative images for MX1 IHC (brown staining) from biopsies collected prior to dosing (baseline) and during the fourth dosing week (treatment) are presented. Scale bars=100 µm. (c–f) Plots show the number of cell profiles expressing MX1 (c–d) or ISG15 (e–f) at baseline and during MGN1703 treatment (n=11 in all graphs). Gray circles indicate results for each individual. Paired data are connected with gray lines. Black squares represent the mean value for all individuals at the indicated time point. Black lines connect longitudinal mean data points. (c and e) The numbers of positive cell profiles per mm2 within the lamina propria regions are illustrated. (d and f) The numbers of positive cell profiles per mm2 within the epithelial regions are illustrated. Statistics: Wilcoxon matched-pairs signed rank test.