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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Mucosal Immunol. 2017 Aug 2;11(2):449–461. doi: 10.1038/mi.2017.59

Figure 5. MGN1703-induced reductions in intestinal mononuclear cell HIV-1 DNA copies is associated with higher baseline TLR9 and IFNAR1 expression.

Figure 5

(a, c and e) Bi-variant plots show the fold change in the copies of integrated HIV-1 DNA (left axis) versus the baseline number of TLR9 transcripts (a), the baseline number of IFNAR1 (IFN-α receptor alpha chain) transcripts (c) or the MGN1703-induced fold-change in transcription of IL17RE (IL-17 receptor E) (e). Spearman correlation r and p values are shown. (b, d and f) Data for the baseline number of TLR9 transcripts (b), the baseline number of IFNAR1 transcripts (d) or the MGN1703-induced fold-change in transcription of the IL17RE gene (f) were stratified based on whether the reduction in integrated HIV-1 DNA copies was greater or less than 50%. The HIV-1 DNA values were generated from isolated mononuclear cells. Statistics: Wilcoxon matched-pairs signed rank test.