Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jan 29;9:75. doi: 10.3389/fimmu.2018.00075

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Patra and Choi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Structural organization of individual domains of toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP). (A) The overall structure of a modeled TIR domain dimer. (B) A predicted model of the N-terminal domain (NTD). (C) Initial model (energy minimized) of a full-length TIRAP with the NTD and TIR domains arranged in a physiological dimeric condition. (D) A closer view of the dimer interface between TIR monomers involving residues from αC′ and αD helices. (E) A detailed view of the NTD dimerization, including residues from both phosphatidylinositol (PI)-binding motif (PBM) and PI-binding domain (PBD). (F) A 90° rotated view of panel (E) for clarity. Dashed lines represent hydrogen bonds, and digits indicate distances in angstrom units.