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. 2017 Dec 17;9(4):4451–4460. doi: 10.18632/oncotarget.23377

Figure 1. Altered expression of fibrosis-related genes and miRNAs in co-culture experiments.

Figure 1

(A) Increased expression of α-SMA, PDGFRβ, and COL1A1 in hPSC21-S/T (hPSCs) after 72 hours of co-culture with PDAC cells. (B) MiRNA profiling assays demonstrating altered expression of several miRNAs including mir-328, mir-382, and mir-let-7d in hPSCs co-cultured with PDAC cells compared to hPSCs alone. (C) Real-time PCR demonstrating altered miRNA expression in the co-cultures. (D) Analysis of differences in miRNA expression between PDAC (n = 183) and normal tissue (n = 4) was evaluated by real-time PCR. Only let-7d showed consistently reduced expression. The opposite results were observed for mir-328, and no changes in mir-382 expression were observed. *P < 0.05.