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. 2017 Dec 15;9(4):4461–4474. doi: 10.18632/oncotarget.23286

Figure 3. Effect of PLCγ1 inhibitor on Aggrecan expression in a rat OA model.

Figure 3

Specimens were longitudinally cut into 3 μm sections and the levels of Aggrecan expression level were detected by immunohistochemisty technique (original magnification ×200). As described in Material and Methods, the positive chondrocytes were counted and analyzed using Image-Pro Plus 6.0 Software and GraphPad Prism version 5. (A) Representative images from rats treated by PLCγ1 inhibitor for 1 month after ACLT+MMx (original magnification ×200). Graph indicating the percentage of positive chondrocytes expressing Aggrecan (***P < 0.001, vs normal group). (B) Representative images from rats treated by PLCγ1 inhibitor for 2 month after ACLT+MMx (original magnification ×200). Graph indicating the percentage of positive chondrocytes expressing Aggrecan.