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. 2017 Dec 17;9(4):4496–4510. doi: 10.18632/oncotarget.23388

Figure 1. Shh signaling components are up-regulated in thyroid tumors.

Figure 1

(A) Representative histological sections from normal thyroid (NT), PTC and ATC incubated with a mouse monoclonal anti-Gli1 antibody. ATC samples showed intense immunoreactivity for Gli1, PTC samples showed a mild expression of Gli1 while normal thyroid tissues were completely negative. Negative controls were performed in all cases using isotype-matching control antibodies. (B) Q-RT-PCR of Gli1 was performed in five normal thyroids (NT), eight PTCs and six ATCs tumor samples. The fold induction was calculated using the pool of the five normal thyroid tissues as control (N). The results are the average of three independent experiments. Error bars represent standard deviations of three independent experiments. **p = ≤ 0.01; *p = ≤ 0.05.