Table 1. Characteristics of the whole-population and low-risk and high-risk groups based on PFS and OS-pPET-RadScores.
| Characteristics | All patients | PFS-pPET-RadScore | OS-pPET-RadScore | ||||
|---|---|---|---|---|---|---|---|
| Low-risk group | High-risk group | P | Low-risk group | High-risk group | P | ||
| Subjects | 47 | 42 | 5 | 33 | 14 | ||
| Cutoff pPET-RadScore | NA | <0.09 | >0.09 | <0.11 | >0.11 | ||
| Age, years | 68 (61–73) | 68 (62–72) | 73 (51–75) | 0.64 | 69 (66–72) | 63 (55–74) | 0.31 |
| Female | 6 (12.8) | 5 (11.9) | 1 (20) | 0.61 | 4 (12.1) | 2 (14.3) | 0.84 |
| Comorbidities | |||||||
| Hypertension | 17 (36.2) | 16 (38.1) | 1 (20) | 0.43 | 13 (39.4) | 4 (28.6) | 0.48 |
| Type 2 diabetes mellitus | 15 (31.9) | 15 (35.7) | 0 (0) | 0.11 | 13 (39.4) | 2 (14.3) | 0.09 |
| Coronary artery disease | 6 (12.8) | 6 (14.3) | 0 (0) | 0.37 | 5 (15.2) | 1 (7.1) | 0.45 |
| HCC characteristics | |||||||
| Tumor size, cm | 6.0 (4.3–9.0) | 5.5 (3.8–8.4) | 8.9 (8.6–9.4) | 0.05 | 4.8 (3.4–7) | 8.8 (6.2–11) | 0.02 |
| <5 cm | 19 (40.4) | 19 (45.2) | 0 (0) | 0.05 | 17 (51.5) | 2 (14.3) | 0.02 |
| ≥5 cm | 28 (59.6) | 23 (54.8) | 5 (100) | 0.05 | 16 (48.5) | 12 (85.7) | 0.02 |
| Uni-nodular | 24 (51.1) | 21 (50) | 3 (60) | 0.67 | 14 (42.4) | 10 (71.4) | 0.07 |
| Multi-nodular (2–5 nodules) | 5 (10.6) | 5 (11.9) | 0 (0) | 0.41 | 5 (15.2) | 0 (0) | 0.12 |
| Diffuse (> nodules) | 18 (38.3) | 16 (38.1) | 2 (40) | 0.93 | 14 (42.4) | 4 (28.6) | 0.37 |
| PVI | 21 (44.7) | 20 (47.6) | 1 (20) | 0.24 | 14 (42.4) | 7 (50) | 0.63 |
| Serum AFP level, kUI/l | 17 (6–192) | 15 (6–124) | 1507 (6–4430) | 0.42 | 12.7 (5-81) | 119 (6–3699) | 0.37 |
| BCLC staging system | |||||||
| Stage A | 3 (6.4) | 3 (7.1) | 0 (0) | 0.54 | 3 (9.1) | 0 (0) | 0.24 |
| Stage B | 18 (38.3) | 17 (40.5) | 1 (20) | 0.37 | 14 (42.4) | 4 (28.6) | 0.37 |
| Stage C | 26 (55.3) | 22 (52.4) | 4 (80) | 0.24 | 16 (48.5) | 10 (71.4) | 0.15 |
| Ascites | 7 (14.9) | 7 (16.7) | 0 (0) | 0.32 | 5 (15.2) | 2 (14.3) | 0.94 |
| Cirrhosis | 44 (93.6) | 40 (95.2) | 4 (80) | 0.19 | 32 (97) | 12 (85.7) | 0.15 |
| Child-Pugh score A | 36 (76.6) | 33 (78.6) | 3 (60) | 0.35 | 27 (81.8) | 9 (64.3) | 0.19 |
| Child-Pugh score B (≤B7) | 8 (17) | 7 (16.7) | 1 (20) | 0.85 | 5 (15.2) | 3 (21.4) | 0.60 |
| Chronic alcoholism | 24 (51.1) | 22 (52.4) | 2 (40) | 0.60 | 17 (51.5) | 7 (50) | 0.92 |
| Viral infection type B, C | 17 (36.2) | 16 (38.1) | 1 (20) | 0.43 | 12 (36.4) | 5 (35.7) | 0.97 |
| Hemochromatosis | 2 (4.3) | 2 (4.8) | 0 (0) | 0.62 | 2 (6.1) | 0 (0) | 0.35 |
| NASH | 5 (10.6) | 5 (11.9) | 0 (0) | 0.41 | 5 (15.2) | 0 (0) | 0.12 |
Values are median (25th; 75th interquartile range) or n (%). AFP, alpha-fetoprotein; HCC, hepatocellular carcinoma; BCLC, barcelona-clinic liver cancer; PVI, portal vein invasion; NASH, non-alcooholic steatohepatitis; TARE, transarterial radioembolization