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Vehicle or sunitinib treatment in control (A) sensitive (B) and resistant (C–D) xenograft groups. Arrows show treatment start points. Mice were sacrified at the time points indicated by stars [*]. Sunitinib treatment resulted in stability of tumor volume for 3 weeks (no tumor regrowth) compared to control group. Resistance started to develop after four weeks of treatment and tumors grew rapidly after 6-7 weeks.
