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. 2017 Dec 8;9(4):4661–4674. doi: 10.18632/oncotarget.23163

Figure 4.

Figure 4

(A) Molecular Function Analysis of miRNA changes in sunitinib resistant tumors. (B) Comparison of Diseases and BioFunction analysis of mRNA and miRNA sequencing between sunitinib resistant and sensitive xenograft tumors. BioFunction Terms are grouped by similar biological role (blue circles). Lines among similar BioFunction groups indicate connections in function. The clustered BioFunctions altered in mRNA expression profiling related to angiogenesis, immune response, cell movement were all significant in network with calcium signaling and cell proliferation. Other BioFunction terms related to vasculogenesis, cell migration and leukocyte activation were significant in both mRNA and miRNA sequencing results.