Table 2. Basic characteristics and allele frequencies of the six SNPs.
SNP | Genes | Chr | Position | Allele | Minor allele frequency | HWE P value | OR (95%CI) | Pa | |
---|---|---|---|---|---|---|---|---|---|
Case | Control | ||||||||
rs2277698 | TIMP2 | 17q25.3 | 76867017 | C>T | 0.247 | 0.237 | 0.7265 | 1.06 (0.79–1.41) | 0.711 |
rs2009196 | TIMP2 | 17q25.3 | 76870581 | G>C | 0.508 | 0.458 | 0.7013 | 1.22 (0.95–1.57) | 0.112 |
rs7342880 | TIMP2 | 17q25.3 | 76874512 | C>A | 0.177 | 0.215 | 0.4525 | 0.78 (0.57–1.07) | 0.129 |
rs11654470 | TIMP2 | 17q25.3 | 76877331 | T>C | 0.327 | 0.333 | 0.8865 | 0.98 (0.75–1.27) | 0.858 |
rs2003241 | TIMP2 | 17q25.3 | 76885117 | T>C | 0.218 | 0.271 | 0.1096 | 0.75 (0.56–1.00) | 0.050 |
rs4789936 | TIMP2 | 17q25.3 | 76897974 | C>T | 0.227 | 0.300 | 0.7632 | 0.68 (0.51–0.91) | 0.009* |
SNP: single nucleotide polymorphism; OR = odds ratio; 95% CI = 95% confidence interval;
HWE: Hardy-Weinberg equilibrium;
*P < 0.05 indicates statistical significance;
aP values were calculated using two-sided Chi-squared test/Fisher's exact test.