Table 1. Correlation between SMOC1 methylation and the clinicopathological features of non-invasive colorectal tumors.
| SMOC1 methylation | |||
|---|---|---|---|
| <36% (n = 376) | ≥36% (n = 97) | P | |
| Age (y, mean ± SD) | 64.0 ± 11.1 | 68.6 ± 11.2 | <0.001 |
| Gender | |||
| Female | 112 | 31 | NS |
| Male | 264 | 66 | |
| Location | |||
| Proximal | 186 | 50 | NS |
| Distal | 190 | 47 | |
| Size (mm, mean ± SD) | 10.6 ± 6.8 | 18.1 ± 13.0 | <0.001 |
| Morphology | |||
| Depressed | 2 | 1 | NS |
| Flat | 192 | 63 | |
| Flat plus protruding | 14 | 9 | |
| Protruding | 136 | 58 | |
| Histology | |||
| HP | 51 | 1 | <0.001 |
| SSA/P | 104 | 3 | |
| SSA/P + CD | 23 | 3 | |
| SSA/P + cancer | 11 | 3 | |
| TSA | 31 | 16 | |
| TSA + cancer | 0 | 8 | |
| Low-grade adenoma | 64 | 10 | |
| High-grade adenoma | 53 | 32 | |
| Cancer | 39 | 21 | |
| BRAF | |||
| Mut | 151 | 19 | <0.001 |
| WT | 225 | 78 | |
| KRAS | |||
| Mut | 74 | 50 | <0.001 |
| WT | 302 | 47 | |
| TP53 | |||
| Mut | 26 | 14 | 0.018 |
| WT | 350 | 83 | |
| CIMP status | |||
| Negative | 248 | 57 | 0.010 |
| Low | 50 | 25 | |
| High | 78 | 15 | |
| MLH1 methylation | |||
| Methylated | 18 | 2 | NS |
| Unmethylated | 358 | 95 | |
NS, not significant; CD, cytological dysplasia; Mut, mutated; WT, wild type.