Table 2. Correlation between SMOC1 methylation and the clinicopathological features of invasive colorectal tumors.
| SMOC1 methylation | |||
|---|---|---|---|
| <36% (n = 235) | ≥36% (n = 139) | P | |
| Age (y, mean ± SD) | 66.3 ± 12.2 | 70.6 ± 10.6 | <0.001 |
| Gender | |||
| Female | 84 | 64 | NS |
| Male | 151 | 75 | |
| Location | |||
| Proximal | 86 | 71 | 0.006 |
| Distal | 149 | 68 | |
| Morphology | |||
| Type 0 | 44 | 18 | NS |
| Depressed | 30 | 8 | |
| Flat | 7 | 7 | |
| Flat plus protruding | 0 | 0 | |
| Protruding | 7 | 3 | |
| Type 1 | 21 | 17 | |
| Type 2 | 151 | 102 | |
| Type 3 | 10 | 2 | |
| Type 4 | 0 | 0 | |
| Type 5 | 9 | 0 | |
| BRAF | |||
| Mut | 19 | 4 | NS |
| WT | 216 | 135 | |
| KRAS | |||
| Mut | 48 | 72 | <0.001 |
| WT | 187 | 67 | |
| TP53 | |||
| Mut | 56 | 31 | NS |
| WT | 179 | 108 | |
| CIMP status | |||
| Negative | 200 | 88 | <0.001 |
| Low | 24 | 38 | |
| High | 11 | 13 | |
| MLH1 methylation | |||
| Methylated | 13 | 2 | NS |
| Unmethylated | 222 | 137 | |
| pT category | |||
| pT1 | 33 | 14 | NS |
| pT2 | 32 | 28 | |
| pT3 | 125 | 81 | |
| pT4 | 25 | 9 | |
| NA | 20 | 7 | |
| pN category | |||
| pN0 | 140 | 83 | NS |
| pN1 | 47 | 35 | |
| pN2 | 22 | 13 | |
| NA | 26 | 8 | |
| pM category | |||
| pM0 | 184 | 120 | NS |
| pM1 | 31 | 15 | |
| NA | 20 | 4 | |
| Lymphatic invasion | |||
| Negative | 59 | 40 | NS |
| Positive | 140 | 85 | |
| NA | 36 | 14 | |
| Vascular invasion | |||
| Negative | 85 | 58 | NS |
| Positive | 113 | 67 | |
| NA | 37 | 14 | |
NS, not significant; Mut, mutated; WT, wild type; NA, not available.