Figure 2.

(A–B) Quantification of IFN-γ and granzyme B secretion by ELISA. Secretion of IFN-γ and granzyme B in response to the stimulation with one of the respective peptides was analyzed by quantitative ELISA after in vitro antigen-specific stimulation over seven days (n = 5). The referential antigens (A*03_EBNA3A_RLRA, EBV_Consensus) were additionally employed as antigenic stimuli. Results of (A) IFN-γ and (B) granzyme B secretion (pg/ml) are shown for each of the peptides and EBV_Consensus+4P_MIX as the percentage concentration in reference to the peptide A*03_EBNA3A_RLRA, which is set to a comparative value of 100%. They are displayed as means ± SD. Asterisks indicate statistically significant differences between the EBV-specific peptides and A*03_EBNA3A_RLRA (^***p < 0.001).