Table 2. Serum expression levels of three tumor markers and survival of GC patients in all sample sets.
Combined tumor marker Data set | Patients | Deaths | MST (months) | P Valuea | 95%CI |
---|---|---|---|---|---|
CEA | |||||
Low, ≤2.48 | 863 | 306 | 25.03 | ||
High, >2.48 | 703 | 337 | 18.90 | <0.001 | 1.509(1.293,1.762) |
CA19-9 | |||||
Low, ≤28.81 | 1246 | 455 | 24.47 | ||
High, >28.81 | 320 | 188 | 16.30 | <0.001 | 1.957(1.650, 2.321) |
CA72-4 | |||||
Low, ≤2.47 | 1025 | 396 | 24.97 | ||
High, >2.47 | 541 | 247 | 17.67 | <0.001 | 1.417(1.209, 1.662) |
No. of high risk tumor marker(ref:0) | 525 | 169 | 27.80 | <0.001 | |
1 | 610 | 236 | 22.90 | 0.003 | 1.352(1.110, 1.648) |
2 | 339 | 178 | 18.13 | <0.001 | 2.033(1.647, 2.510) |
3 | 92 | 60 | 11.15 | <0.001 | 3.263(2.427, 4.386) |
CEA, carcino-embryonic antigen; CA19-9, carbohydrate antigen 19-9; CA72-4, carbohydrate antigen 72-4; No, number.
a Cox proportional hazards model.