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. 2017 Dec 18;9(4):4833–4850. doi: 10.18632/oncotarget.23373

Figure 8. The diagram of our proposed working model.

Figure 8

BMP2 stimulates SATB2 expression and this up-regulation could be significantly inhibited by TNF-α, TNF-α inhibits BMP2 induced smad1/5/8 signaling, activates pERK1/2 and p38 signaling, in addition, TNF-α stimulates NF-κB signaling which results in translocation of p65 into nuclear and binds to SATB2 promoter to suppress SATB2 expression. Furthermore, the expression of osteoblast differentiation marker genes and osteoblastogenesis were inhibited.